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Physical dependence on physiologically released endogenous opiates

, : Physical dependence on physiologically released endogenous opiates. Life Sciences 30(14): 1173-1178

Mice which had been submitted to a chronic schedule of warm water swimming exhibited a naloxone precipitated withdrawal behavior which was remarkably similar to that produced in mice following chronic morphine treatment. These results are consistent with the activation of endogenous opiates during swim stress in mice and present the possibility that opiate receptors are activated in a manner analogous to the repeated application of exogenous opiates, producing both tolerance and withdrawal-like behavior.


PMID: 7201057

DOI: 10.1016/0024-3205(82)90659-2

Other references

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