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Piperacillin vs. clindamycin plus gentamicin for pelvic infections

, : Piperacillin vs. clindamycin plus gentamicin for pelvic infections. Obstetrics and Gynecology 64(6): 762-766

Piperacillin, a new semisynthetic penicillin, has broad spectrum activity against most clinically important aerobic and anaerobic bacteria. Piperacillin was compared with a combination of clindamycin and gentamicin for the treatment of 83 women with pelvic infection (42 with endometritis, 29 with posthysterectomy cuff infections, 11 with acute salpingitis, and 1 with a wound infection). There were 179 bacterial isolates, 98 (53%) aerobic and 81 (45%) anaerobic. Of the 42 patients treated with piperacillin, there were three (7.1%) clinical failures compared with one (2.4%) in the 41 patients treated with clindamycin-gentamicin. A single drug, piperacillin, was as safe and effective as the combined clindamycin plus gentamicin therapy for pelvic infections.


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