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Pituitary and ovarian function in women receiving hormonal contraception

, : Pituitary and ovarian function in women receiving hormonal contraception. Contraception 24(2): 159-172

Pituitary and ovarian function was evaluated in women receiving 3 combined oral contraceptive preparations. Basal levels of FSH and luteinizing hormone (LH) and gonadotropic responses to gonadotropin releasing hormone (GnRH) were studied in 36 healthy, regularly ovulating women in the early follicular and mid-luteal phases of their menstrual cycle (non-treatment, control). These same women were then divided into 3 groups with 12 volunteers in each. Each group received an oral contraceptive preparation cyclically for 3 mo. The preparations were Nordette (30 .mu.g ethinyl estradiol and 150 .mu.g d-norgestrel), Nordiol (50 .mu.g ethinyl estradiol and 250 .mu.g d-norgestrel) and Biphasil (50 .mu.g ethinyl estradiol and 50 .mu.g d-norgestrel .times. 11 days and 125 .mu.g d-norgestrel .times. 10 days). In the 3rd month of treatment, the tests were repeated on day 21, i.e., after 21 active pills, and on day 28, i.e., after 21 active and 7 inactive tablets. On active therapy, basal FSH and LH were similarly suppressed in the 3 groups. LH had varied responses to a bolus of GnRH, while the FSH response were similar in the 3 groups. After 7 days of inactive tablets, basal FSH and LH had returned to pretreatment, early follicular phase levels. The LH responses to a bolus of GnRH varied in the 3 groups, but again, no differences were noted in the FSH responses. Basal FSH, LH and estradiol recovered earlier in the Nordette group during the 7 days of inactive tablets.


DOI: 10.1016/0010-7824(79)90053-2

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