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Plasmodium berghei: relationship between mitosis and erythropoiesis in spleen cells of infected rats

, : Plasmodium berghei: relationship between mitosis and erythropoiesis in spleen cells of infected rats. Experimental Parasitology 43(2): 362-369

Rats rendered polycythemic by hypoxia show a suppression of erythropoiesis and a rebound granulo- and lymphopoiesis in the posthypoxic period. These rats, when infected with P. berghei had a survival rate of 80%, as compared to 8% in normally infected controls. 59Fe and [3H]thymidine uptake of spleen cells was measured from the initiation until peak parasitemia. As the infection progressed, the ratio of 3H to 59Fe uptake declined from 37.00 to 1.40, showing a shift towards erythropoiesis. Rebound animals showed a marked decrease in Fe uptake when infected, especially during the early stages of infection. Changes in the balance between the formation of erythropoiesis-oriented cells and of immune-oriented cells in the rat spleen may prove critical to the fate of the malaria-infected animal.


PMID: 598448

DOI: 10.1016/0014-4894(77)90041-8

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