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Predisposing factors in Pneumocystis carinii pneumonia: effects of tetracycline, protein malnutrition, and corticosteroids on hosts


, : Predisposing factors in Pneumocystis carinii pneumonia: effects of tetracycline, protein malnutrition, and corticosteroids on hosts. Infection and Immunity 46(3): 747-753

Components of the immunosuppressive regimen used to reactivate latent Pneumocystis carinii infection were analyzed for their effects on the growth, nutrition, and lymphoid system of hosts. Rats that were administered either tetracycline or a low-protein (8%) diet alone for 7 weeks developed few abnormalities, but animals on the combined regimen developed lower body and lymphoid organ weights, lower serum albumin levels, and fewer circulating lymphocytes. Rats that were administered corticosteroids and tetracycline experienced severe wasting, debilitation, and generalized lymphocyte depletion; the low-protein diet increased the magnitude of these changes. Alterations in the frequency of occurrence of specific lymphocyte subsets occurred only in rats given corticosteroids and consisted mainly of a greater decline in peripheral blood T helper cells than in T suppressor cells. The data suggest that long-term tetracycline administration and a low-protein diet have a variety of adverse effects on the host which enhance the immunosuppressive properties of corticosteroids.

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PMID: 6334032


Other references

Pearson, A.J.; Hwang, J.J., 2000: Preparation of donor-sigma-acceptor molecules using arene-ruthenium chemistry. Several donor-sigma acceptor (D-sigma-A) molecules with thioalkyl side chains have been prepared by ruthenium-activated nucleophilic aromatic substition (S(N)Ar) reactions. Selective substitution of chloride from cyclopentadienyl(1,4-dichlorobenze...

Pugliese, A.; Negro Ponzi, A., 1975: Action of a synthetic peptide on some syngeneic tumors. The protective effect of intraperitoneal Peptichemio at different doses in a population of syngeneic mice with four experimental tumours is described. The drug is much used in oncology en account of its low toxicity and is both alkylating and anti...

Feldmann, M.; Palmer, J., 1971: The requirement for macrophages in the secondary immune response to antigens of small and large size in vitro. Immunology 21(4): 685-699

Evrard, J.; Burghart, P., 1998: CETIOMs oil mill pilot plant. Fett 100(8): 395, Aug

Smith, G.M.; Coates, C.W.; Strong, L.C., 1936: Neoplastic diseases in small tropical fishes. Several neoplastic diseases are described: "Melanotic Over-growths" and a red pigmented tumor (erythro-phoroma) in hybrids of Xiphophorus helleri and Platy-poecilus maculatus; fibroma in Rasbora daniconius; adenocarcinoma of the thyroid...

Rosazza J.P.N.; Duffel M.W.; Thede B.M.; Sariaslani F.S.; Goswami A.; Filippelli F.; Schaumberg J.P., 1987: Microbial chemical and enzymatic transformations of alkaloids. Bulgarian Academy Of Sciences (Ed ) F E C S Third International Conference on Chemistry And Biotechnology Of Biologically Active Natural Products, Vol 1 Main Plenary Lectures; Meeting, Sofia, Bulgaria, September 16-21, 1985 Viii+280p Vch Publishers, Inc : New York, New York, Usa; Weinheim, West Germany Illus Paper 73-95

Franke, R.W., 1993: Feeding programmes and food intake in a Kerala village. The distribution of food through ration shops and feeding programmes in Kerala, India is examined.

Krasnov, I.B.; Babichenko, I.I.; Afonin, B.V.; Pankova, A.S., 1986: Morphological and biochemical analysis of the organs and tissues of rats following a 30-day exposure to increased gravitational forces of 1.1 and 2.0 G. During 30 days rats were centrifuged at 1.1 and 2.0 G. On centrifugation day 30 the rats showed body mass losses, decrease of plasma ACTH, activation of the renin-angiotensin-aldosterone system (RAAS) and ultrastructural changes in the mossy fiber...

Ndirangu, J.; Newell, M-Louise.; Tanser, F.; Herbst, A.J.; Bland, R., 2011: Decline in early life mortality in a high HIV prevalence rural area of South Africa: evidence of HIV prevention or treatment impact?. Objective: We present early life mortality rates in a largely rural population with high antenatal HIV prevalence, and investigate temporal and spatial associations with a prevention of mother-to-child transmission (PMTCT) programme, an HIV treatm...

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