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Preliminary data on different endothelial concanavalin a reactivity at different arterial tree levels in rabbits and cynomolgus monkeys


, : Preliminary data on different endothelial concanavalin a reactivity at different arterial tree levels in rabbits and cynomolgus monkeys. Bollettino Societa Italiana Biologia Sperimentale 57(21): 2176-2178

Delayed appearance of atherosclerotic lesions in cerebral arteries was observed not only in man but also in monkeys and rabbits submitted to atherogenic diets. Previous observations had shown a Con A (.eta.oncanavalin A] positive reaction (glycocalyx or surface coat) at the luminal surface and in the plasmalemmal vesicles of aortic endothelial cells of rabbits and other laboratory animals. The surface coat is now reputed to be the site of lipoprotein lipase activity whose importance in atherogenesis was recently stressed. The endothelial cells Con A reactivity after Bernhard and Avrameas, which was not previously studied in the cerebral arteries of rabbits and monkeys, was always lacking in this arterial district. Those observations may help explain the delayed appearance of atherosclerotic lesions in cerebral arteries.

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