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Preservation of the antibiotic producing ability of a streptomycete by lyophilizing for 13 years


, : Preservation of the antibiotic producing ability of a streptomycete by lyophilizing for 13 years. Institute for Fermentation Research Communications (Osaka) (12): 101-106

The cultured broth of the L strain of aristeromycin producer, Streptomyces citricolor IFO 13005, which was revived from a lyophilized ampule preserved for 13 yr at 8.degree. C, showed the same antimicrobial spectrum as that of M strain of the same producer which was maintained for the same period by transplanting from agar medium to agar medium at intervals of 3 or 6 mo. From the broth, antibiotic having the same physicochemical properties and NMR spectrum of aristeromycin was isolated. The antibiotic producing ability of this streptomycete was preserved for a long period in the lyophilized state, while decreased by transplantation on agar medium.

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