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Pulmonary fibrosis a complication of 1 3 bis 2 chloroethyl 1 nitroso urea therapy

, : Pulmonary fibrosis a complication of 1 3 bis 2 chloroethyl 1 nitroso urea therapy. Cancer 48(4): 909-911

A pediatric patient is reported who experienced fatal progressive pulmonary fibrosis as a complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. The patient received a cumulative dosage of 1.29 g (1.72 g/m2) over a 2 yr period as adjuvant therapy for a medulloblastoma. At 2 1/2 yr after cessation of therapy, cough, tachypnea and fatigue were noted. Progressive pulmonary insufficiency developed. Pulmonary pathologic findings included interstitial fibrosis and alveolar dysplasia. Other cases of BCNU pulmonary toxicity are cited from the medical literature.


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