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Radionuclide angiography in the study of left ventricular ejection and filling rates


, : Radionuclide angiography in the study of left ventricular ejection and filling rates. Cardiologia (Rome) 28(6): 459-469

A study was carried out in 1/6 male subjects divided in 7 normal subjects (group A) and in 9 subjects with coronary artery disease (group B). In all subjects, in supine and left anterior oblique position, computerized ECG gated radionuclide left ventricular angiography was performed using i.v. human serum albumin labeled with 20-25 mCi of 99mTc. The data were collected before and after sublingual nitroglycerin 0.6 mg (TNG). Left ventricular ejection fraction was smaller (P < 0.05) in group B of the coronary patients compared with group A. In group B the peak ejection rate and the peak filling rate were smaller (P < 0.05). Linear regressions between the ejection fraction and the ejection and filling rates were not statistically significant. The time to peak ejection rate was similar in both groups considered; the time to peak filling rate was more prolonged (P < 0.05) in the group of coronary patients. TNG did not induce substantial changes in ejection fraction in both groups. TNG determined a similar growth of ejection and filling rates, but not statistically significant; the number of cases was small and the data presented a great variability. The radionuclide angiography shows a damage of left ventricular systolic function and of myocardial relaxation in coronary artery disease; that was reduced by oral TNG. These data suggest the interest of employing this method in a non-invasive study of the contractile performance and left ventricular filling in different forms of cardiac pathology.

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