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Rapid fatigue of neuro peptide secretion during continual electrical stimulation

, : Rapid fatigue of neuro peptide secretion during continual electrical stimulation. Neuroendocrinology 35(6): 424-428

The vasopressin released by electrical stimulation of the isolated rat neurohypophysis into continuously perifused medium was measured by specific radioimmunoassay. The peak secretory rates achieved in the first few minutes of a period of 13-Hz stimulation are not maintained, but decline to a plateau level, above the level of basal secretion, but markedly below the initial stimulated rate. After mathematical correction of the measured profile of peptide secretion to take account of the delayed appearance in the perifusate of hormone released from the interior of the gland it appears that peak secretory rates are not maintained beyond the first 2 min of stimulation; thereafter, stimulated secretion is stable at about 10% of the peak rate.


PMID: 7155300

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