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Regulation of calcitonin and parathyroid hormone secretion by estrogens


, : Regulation of calcitonin and parathyroid hormone secretion by estrogens. Maturitas 4(1): 1-8

Calcitonin is a peptide hormone secreted by C-cells which, in humans, are found mainly in the thyroid gland. A major physiological function of this hormone in man is the long-term maintenance of the skeleton achieved by control of bone resorption. A marked sex difference in circulating calcitonin levels normally exists, with a relative deficiency in women as compared to men. Estrogens regulate calcitonin secretion; the loss of ovarian function at the menopause accelerates the natural decline in calcitonin secretion which occurs with age. Thus, post-menopausal women are more markedly calcitonin-deficient. Levels of the bone-resorbing hormones, parathyroid hormone and 1,25-dihydroxyvitamin D are not elevated post-menopausally. The increased bone resorption which leads to post-menopausal bone loss apparently is due mainly to the loss of estrogen and calcitonin secretion.

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PMID: 6896553


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