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Response of pancreatic immuno reactive somatostatin to arginine


, : Response of pancreatic immuno reactive somatostatin to arginine. Life Sciences 19(12): 1957-1959

Perfusion of isolated dog pancreases with arginine (20 mM) was associated with a prompt and sustained increase in immunoreactive somatostatin (IRS) in the venous effluent, while insulin and glucagon rose promptly but soon receded from their peak levels. These results are compatible with a postulated feedback relationship between somatostatin-, glucagon- and perhaps insulin-secreting cells of the islets in which somatostatin, stimulated by local glucagon, restrains glucagon secretion and perhaps glucagon-mediated insulin release as well.

US$29.90

PMID: 794612


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