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Role of alveolar macrophages in development of paraquat induced lung injury


, : Role of alveolar macrophages in development of paraquat induced lung injury. Lung 161(1): 47-56

To learn if AM [alveolar macrophages] are related to the initiation of paraquat-induced lung injury in rats, an i.p. injection of 10 mg/kg paraquat was followed by a rapid increase in the number of viable AM. This effect reached a maximum at 24 h after injection. When 90 mg/kg of methylprednisolone was injected s.c. at the same time of the administration of paraquat, there was no increase in the number of viable AM. After weekly injection of 5 mg/kg paraquat for 6 wk, there were histological changes which were significantly supressed by the simultaneous administration of methylprednisolone. Methylprednisolone did not show such supressive effects when administered 4 d [days] after the injection of paraquat. The emergence of viable AM is one of the key phenomena in the initiation of interstitial changes in paraquat-induced lung injury.

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