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Self administration of the endogenous trace amines beta phenethylamine n methyl phenethylamine and phenethanolamine in dogs


, : Self administration of the endogenous trace amines beta phenethylamine n methyl phenethylamine and phenethanolamine in dogs. Journal of Pharmacology & Experimental Therapeutics 222(1): 52-60

.beta.-Phenylethylamine and phenylethanolamine are biogenic amines structurally related to amphetamine which occur endogenously in trace amounts in mammalian brain. Whether these endogenous biogenic amines, like amphetamine, have reinforcing properties was determined. Dogs surgically prepared with i.v catheters were permitted 4-h daily access to i.v. infusions of .beta.-phenylethylamine, phenylethanolamine, N-methylphenylethylamine, cocaine or d-amphetamine under a fixed-ratio 1-response schedule of reinforcement. In dogs which had not previousy self-administered drugs, the number of infusions self-administered per session of .beta.-phenylethylamine, N-methyl phenylethylamine and cocaine increased above that for saline typically within 5-10 sessions. Increases in the number of injections per session were observed in only 2 of 5 dogs with phenylethanolamine, and in only 3 of 5 dogs with d-amphetamine within as many as 20-40 sessions. Dose-effect curves were determined in dogs which were trained previously to self-administer drug and those daily drug intake was stable. The relative potencies of these compounds in maintaining self-administration behavior during the 4-h session were d-amphetamine > cocaine .mchlt. phenylethanolamine .gtoreq. N-methyl phenylethylamine .gtoreq. .beta.-phenylethylamine. The endogenous trace amines .beta.-phenylethylamine, phenylethylamine and the N-methyl homolog of .beta.-phenylethylamine can function as reinforcers and may play a physiological role in the reinforcement process or in neuropsychiatric disorders.

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