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Serum ferritin in children with blood diseases


, : Serum ferritin in children with blood diseases. Journal of the Nagoya Medical Association 107(1-2): 5-16

Serum ferritin was quantitated by radioimmunoassay to determine the usefulness of this assay in reflecting Fe stores during normal development and in diagnosis of Fe deficiency and hemosiderosis in infants and children. In 117 normal infants and children the concentration of serum ferritin paralleled known changes in Fe stores during development. The medium serum ferritin concentration was 215 ng/ml at birth and then fell to a medium value of between 15 and 19 ng/ml during childhood. In the patients with Fe deficiency anemia, the serum ferritin value was less than normal and became normal after Fe supplement therapy. There was no significant correlation between serum ferritin and ferrioxamine Fe excretion in a patient with hemosiderosis. Serum ferritin concentrations were also determined by radioimmunoassay in patients with leukemia. Serum ferritin concentrations were higher at presentation and relapse than during remission. Serum ferritin concentrations were not correlated with leukemic cells in peripheral blood and bone marrow.

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