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Some aspects of zinc ion involvement in alcohol dehydrogenase catalysis

, : Some aspects of zinc ion involvement in alcohol dehydrogenase catalysis. Bioorganic Chemistry 6(2): 137-156

Alcohol dehydrogenases from various sources catalyze the reaction R.sbd.CHO +NADH + H+ .dblarw. R .sbd.CH2OH + NAD+. The dehydrogenases, the cofactors NADH and NAD+ and their analogues, and the various substrates together constitute one of the most widely studied biochemical reactions. The lines of evidence which lead to a knowledge of the involvement of metal ion in an enzymic reaction are several: the effect of varying metal ion or metal ion content; the effect of metal-chelating agents; variation of cofactor, substrate and inhibitors, together with X-ray, spectrophotometric, kinetic and equilibrium studies are all possible tools. There is the added possiblity of observing analogous nonenzymic reactions which may throw light on the possibilities open to the metal ion as it functions in the enzyme.


DOI: 10.1016/0045-2068(77)90016-5

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