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Spontaneous lymphocyte proliferation and the periodontal status of young adults

, : Spontaneous lymphocyte proliferation and the periodontal status of young adults. Journal of Periodontal Research 18(5): 534-540

Whether the level of incorporation of 3H-thymidine in unstimulated cultures of peripheral blood lymphocytes obtained from young adults differs as a function of their periodontal status was studied. Kinetic studies using normal PBL [peripheral blood lymphocytes] indicated that the rate of 3H-thymidine uptake in unstimulated cultures began to increase markedly by day 5 of culture, peaked .apprx. day 7 and then declined. When this spontaneous lymphocyte proliferative response in young adults with a healthy periodontium (HP) was compared with the response obtained from young adults with severe periodontitis (SP) and individuals with juvenile periodontitis (JP), it was observed that responses in the SP group were markedly depressed at day 5 and day 7. In contrast, responses in the JP group were nearly identical to the HP controls. Periodontal treatment of the SP group appeared to restore normal responsiveness. The most likely bases for these responses is apparently autologous mixed lymphocyte culture reactions. The suppression of the spontaneous response in the untreated SP group may reflect changes in regulatory T-cell function induced by a state of active disease.


PMID: 6227737

DOI: 10.1111/j.1600-0765.1983.tb00390.x

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