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Studies on biological characterization of mammary tumors of the sprague dawley rat in the syngeneic tumor host system part 1 spontaneous primary mammary tumors and tumors induced by oral and intra venous application of di methyl benz anthracene


, : Studies on biological characterization of mammary tumors of the sprague dawley rat in the syngeneic tumor host system part 1 spontaneous primary mammary tumors and tumors induced by oral and intra venous application of di methyl benz anthracene. Archiv fuer Geschwulstforschung 46(7): 549-554

Spontaneous and DMBA[dimethylbenzanthracene]-induced mammary tumors of a Sprague-Dawley inbred line are described. The incidence of spontaneous tumors was 14.3%, and of chemically induced tumors, 43.6%, of all animals tested. Five schedules of application were tested. The method of i.v. application was superior to the oral route with regard to dose, mortality and tumor incidence. Of the carcinomas, 87.2% and of benign tumors, 12.8% developed in the region of the mammary glands following DMBA treatment.

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