geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Studies on blood coagulation activity during storage of red cell products intended for transfusion


, : Studies on blood coagulation activity during storage of red cell products intended for transfusion. Thrombosis Research 40(1): 69-80

Preservation of red blood cells in special media, such as saline-adenine-glucose-mannitol (SAGM) solution involves storage at a citrate and plasma protein concentration much lower than found in normal CPD or CPD-adenine plasma. In the present study, the effects on the coagulation and other connected enzymatic systems in SAGM medium have been investigated. Significantly higher levels of fibrinopeptide A (FPA) and plasma kallikrein activity were observed in the SAGM medium compared to CPD plasma, indicating an increased enzymatic activation in the SAGM medium. For this reason storage of red cells in SAGM solution, supplemented with citrate, was tested and compared with storage in SAGM and CPD plasma. The results demonstrate a positive effect of citrate as an added ingredient in the SAGM solution. Significantly lower levels of primarily FPA but also decreased activities of plasma kallikrein and general proteolysis were noticed. The decreased citrate concentration in red blood cells stored in SAGM protein poor medium must be considered to have a destabilizing influence on the coagulation and on other connected enzymatic systems.

US$19.90

PMID: 4089828

DOI: 10.1016/0049-3848(85)90351-2


Other references

Meuret, G.; Afkham, J.; Schütz, W.; Obrecht, P.; Fliedner, T.M.; Musshoff, K., 1969: Treatment of chronic lymphocytic leukemia by extracorporeal irradiation of the blood. Haematologica Latina 12(3): 531-537

Anonymous, 1958: Neuroleptic drugs in psychiatric therapy. Semaine Medicale Professionelle et Medico-Sociale 34(9): 331-333

Luft, D.; Eggstein, M., 1981: "Hyperthyroiditis". Typical signs of so-called hyperthyroiditis are hyperthyroidism, low iodine uptake by the thyroid, absence of local, general or humoral signs of inflammation, and absence of significant antibody titres against thyroid tissue. These features are il...

Capelli, L., 1961: Stratigraphical study of the lesser circulation after pulmonary exeresis operations. Giornale Italiano Della Tubercolosi E Delle Malattie del Torace 15: 15-23

Nakhjavan-Shahraki, B.; Yousefifard, M.; Oraii, A.; Sarveazad, A.; Hosseini, M., 2017: Meta-analysis of neuron specific enolase in predicting pediatric brain injury outcomes. A reliable biomarker has not been identified to predict the outcome of traumatic brain injury (TBI) in children. Therefore, the present systematic review and meta-analysis aimed to assess the association between neuron specific enolase (NSE) and t...

Dulak, K.R.; Chen, M.; Wilson, R.A.; Glasky, A.J.; Taylor, E.M., 2002: Neotrofintm stimulates the proliferation of neural stem cells in the dentate gyrus but not the sub ventricular zone in adult mice. In adult rodents, neural stem cells (NSC) are found in the dentate gyrus (DG) and the subventricular zone (SVZ). A single dose of Neotrofin (AIT-082), a hypoxanthine derivative with cognition-enhancing, neuroprotective and neurite outgrowth-promot...

Baran, R.; Kopf, A.; Schnitzler, L., 1973: Nasal glioma. Apropos of 4 cases, with electron microscopic study of one case. Annales de Dermatologie et de Syphiligraphie 100(4): 395-407

Mogabgab, W.J.; Haddad, R.J.; Longenecker, S.L.; Buchanan, T.C.; Johnston, R.; Macey, T.I.; Bernard, T.; Floyd, I., 1982: Third-generation beta-lactam antibiotics for treatment of orthopedic infections. Third-generation beta-lactam antibiotics are effective against a wider range of microorganisms than are older antibiotics. Cefotaxime, moxalactam, cefoperazone, ceftizoxime, ceftazidime, cefsulodin, and ceftriaxone were used to treat 102 patients...

Gorden T.B.; Cunningham R.D., 1982: Tobramycin levels in aqueous humor after subconjunctival injection in humans. Subconjuctival injection of 10 mg of tobramycin provided therapeutic levels in the aqueous humor of 25 elderly patients (ranging in age from 51 to 89 yr) who underwent cataract surgery. The absorption from the subconjunctival tissue into the anter...

Barati, Z.; Shewokis, P.A.; Izzetoglu, M.; Polikar, R.; Mychaskiw, G.; Pourrezaei, K., 2013: Hemodynamic response to repeated noxious cold pressor tests measured by functional near infrared spectroscopy on forehead. The objective of this research was to assess the utility of a simple near infrared spectroscopy (NIRS) technology for objective assessment of the hemodynamic response to acute pain. For this exploration, we used functional near infrared spectrosco...