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Studies on glucagon secretion using isolated perfused rat pancreas inhibitory mechanism of glucagon secretion by glucose

, : Studies on glucagon secretion using isolated perfused rat pancreas inhibitory mechanism of glucagon secretion by glucose. Medical Journal of Kobe University 36(2): 81-91

To investigate the mechanism responsible for glucose-induced inhibition of glucagon secretion, the effects of theophylline, hexoses and their metabolites and exogenous insulin on glucagon and insulin secretion were studied in the isolated perfused rat pancreas. Infusion of 5 mM theophylline induced glucagon and insuline secretion and potentiated arginine-induced glucagon and insulin secretion. Metabolizable sugars, 16.7 mM mannose and 16.7 mM fructose, inhibited arginine-induced glucagon secretion and potentiated arginine-induced insulin secretion as did glucose, whereas a non-metabolizable sugar, 10 mM 3-o-methylglucose, did not significantly affect arginine-induced glucagon and insulin secretion. Exogenous porcine insulin (1 .mu.g/ml) had no significant effect on arginine-induced glucagon secretion. 16.7 mM xylitol inhibited arginine-induced glucagon secretion only in its 2nd phase. D-Glyceraldehyde (10 mM) inhibited arginine-induced glucagon secretion, while it stimulated basal insulin secretion and potentiated arginine-induced insulin secretion. Pyruvate (10 mM) inhibited arginine-induced glucagon secretion. Glycolysis beyond the triphosphate step apparently plays an important role in glucose-induced inhibition of glucagon secretion elicited by arginine, although the role of glucoreceptors on A cell membranes could not be ruled out.


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