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Studies on glucagon secretion using isolated perfused rat pancreas inhibitory mechanism of glucagon secretion by glucose


, : Studies on glucagon secretion using isolated perfused rat pancreas inhibitory mechanism of glucagon secretion by glucose. Medical Journal of Kobe University 36(2): 81-91

To investigate the mechanism responsible for glucose-induced inhibition of glucagon secretion, the effects of theophylline, hexoses and their metabolites and exogenous insulin on glucagon and insulin secretion were studied in the isolated perfused rat pancreas. Infusion of 5 mM theophylline induced glucagon and insuline secretion and potentiated arginine-induced glucagon and insulin secretion. Metabolizable sugars, 16.7 mM mannose and 16.7 mM fructose, inhibited arginine-induced glucagon secretion and potentiated arginine-induced insulin secretion as did glucose, whereas a non-metabolizable sugar, 10 mM 3-o-methylglucose, did not significantly affect arginine-induced glucagon and insulin secretion. Exogenous porcine insulin (1 .mu.g/ml) had no significant effect on arginine-induced glucagon secretion. 16.7 mM xylitol inhibited arginine-induced glucagon secretion only in its 2nd phase. D-Glyceraldehyde (10 mM) inhibited arginine-induced glucagon secretion, while it stimulated basal insulin secretion and potentiated arginine-induced insulin secretion. Pyruvate (10 mM) inhibited arginine-induced glucagon secretion. Glycolysis beyond the triphosphate step apparently plays an important role in glucose-induced inhibition of glucagon secretion elicited by arginine, although the role of glucoreceptors on A cell membranes could not be ruled out.

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Other references

Nedwell, D.B.; Raffaelli, D.G., 1999: Advances in Ecological Research; Estuaries. Intended for newcomers and specialists in estuarine ecology, this text with five individually authored chapters provides overviews of topics in estuarine research. Information on how differences in river basins influence loads of nutrients to estu...

Ray Pulak K.; Hayes Miles O.; Stephen Michael F.; Ray Kumkum B., 1973: Multi-level cuspate features on microtidal barrier beaches. Abstracts with Programs - Geological Society of America 5(7): 776-777

Flynn, A.A.; Pedley, R.B.; Green, A.J.; Boxer, G.M.; Boden, R.; Bhatia, J.; Morris, R.; Begent, R.H.J., 2002: Antibody and radionuclide characteristics and the enhancement of the effectiveness of radioimmunotherapy by selective dose delivery to radiosensitive areas of tumour. Purpose: Estimating the absorbed dose to tumour relative to normal tissues has often been used in the assessment of the therapeutic efficacy of radiolabelled antibodies for radioimmunotherapy. Typically, the calculations assume a uniform dose depo...

Cho, K.Y.ung; Choi, S.H.; Kim, C.H.eon; Nam, Y.S.ng; Park, T.G.an; Park, J.K., 2001: Protein release microparticles based on the blend of poly and oligo-ethylene glycol grafted poly. Bovine serum albumin (BSA), a model protein drug, was encapsulated with a microparticle based on the blend of poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactide)-g-oligo(ethylene glycol) (PLLA-g-oligoEG). Effects of PLLA-g-oligoEG in the...

Kucukkurt, S.; Rzayev, S.; Baris, E.; Atac, M.Sancar., 2016: Familial florid osseous dysplasia: a report with review of the literature. There are three types of osseous dysplasia: periapical cemental dysplasia (PCD), focal cemento-osseous dysplasia (FCD) and florid osseous dysplasia (FOD). While PCD is often observed in mandibular anterior teeth, FCD mainly affects mandibular post...

Maksimov, V.P., 1969: Feeding of Thunnus obesus and Xlphiasgladius in the eastern part of the tropical Atlantic. Trudy atlant. nauchno-issled. Inst. Ryb. Khoz. Okeanogr.: 25: 87-99

Michel, B.; Gomez, E., 1992: Diapause of Pectinophora gossypiella (Saunders) (Lep. Gelechiidae) in Paraguay. Diapause of Pectinophora gossypiella was investigated in cotton fields in Paraguay in 1988-89. Virtually all of the final-instar larvae entered diapause, generally from April until November or December. From November onwards, development resumed.

Yamanari, M.; Miura, M.; Makita, S.; Yatagai, T.; Yasuno, Y., 2008: Phase retardation measurement of retinal nerve fiber layer by polarization-sensitive spectral-domain optical coherence tomography and scanning laser polarimetry. Phase retardation of in vivo human retinal nerve fiber layer (RNFL) is quantitatively measured by two methods-polarization-sensitive spectral-domain optical coherence tomography (PS-SD-OCT) and scanning laser polarimetry (SLP). An en face cumulat...

Ofenheim, E.V., 1900: Ueber eine neue Distomidengattung. Zeitschr. Naturw Bd, 73: 145-186

Frasheri A.; Alikaj P.; Frasheri N.; Canga B., 2003: Dipole-dipole array configuration in the framework of the reciprocity principle. The dipole-dipole array configuration is considered as a symmetrical array in terms of the reciprocity principle. This paper, however, demonstrates cases when the IP/Resistivity anomaly configurations observed with a C1C2-P1P2 array is not the sam...