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Studies on serum immunoreactive prolyl 4 hyroxylase in liver diseases its elevation both in hepatocellular damage and cholestatic diseases


, : Studies on serum immunoreactive prolyl 4 hyroxylase in liver diseases its elevation both in hepatocellular damage and cholestatic diseases. Clinica Chimica Acta 175(1): 27-36

The concentration of serum immunoreactive prolyl 4-hydroxylase (S-IRPH) was determined in patients with various liver diseases by the radioimmunoassay developed previously. S-IRPH values were elevated in acute hepatitis (p < 0.01), hepatocellular carcinoma (p < 0.05), metastatic liver neoplasm (p < 0.01) and cholestatic diseases (p < 0.001), but no significant elevation was seen in chronic hepatitis or liver cirrhosis. The mean value of S-IRPH was highest in cholestatic diseases, and next highest in acute hepatitis. In addition to acute hepatitis, S-IRPH was increased in other conditions of hepatocellular damage such as exacerbation of chronic hepatitis or immediately after transcatheter arterial embolization of hepatocellular carcinoma. In cases of hepatocellular damage S-IRPH varied concurrent with cytoplasmic enzyme (AST, ALT and LDH) levels and in cases of cholestatic diseases with biliary enzyme (Al-P and .gamma.GTP) levels. These properties appear to be unique among serum enzymes. The characteristics of S-IRPH were considered to be related to its unique subcellular localization within the cell, ie the membrane of rough endoplasmic reticulum.

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PMID: 2844441


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