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Studies on the growth of a murine renal cell carcinoma and its metastatic patterns

, : Studies on the growth of a murine renal cell carcinoma and its metastatic patterns. Research Communications in Chemical Pathology & Pharmacology 34(2): 345-350

Metastatic lung tumor cells from a murine renal cell adenocarcinoma were implanted in Balb/C mice for 12 transfer generations. Survival time of the implanted mice decreased from 48 to 28 days. The incidence of lung metastases increased from 40 to 90%. These studies suggest a selection process under the terms of the experiment that has resulted in a change in the metastatic potential of the primary tumor and its serial passage of metastases. The results are compatible with current concepts regarding cell selection in this cancer state but do not precisely define how this is achieved.


PMID: 7335958

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