geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Suppression of withdrawal jumping comparison of narcotic tolerance and dependence


, : Suppression of withdrawal jumping comparison of narcotic tolerance and dependence. Drug & Alcohol Dependence 5(6): 401-410

The median and maximal suppressive doses (SD50 and SD95) of methadone and morphine for abrupt withdrawal jumping were determined in male ICR mice (25-30 g) rendered tolerant to and physically dependent on morphine after implantation with a morphine pellet for 3 days. Three separate groups of mice were then given 1 of the following treatments for 5 successive days: SD95 methadone s.c. once daily, SD95 methadone per os (p.o.) once daily and SD95 morphine s.c. every 8 h. Respective controls received either water p.o. or saline s.c. daily. The SD95 for each narcotic suppressed withdrawal jumping equally (by 80%) each day during the 5 day administration period. At the end of that time, only the morphine group demonstrated significant analgetic tolerance to s.c. morphine and methadone (a 3-fold elevation) and detectable physical dependence as evidenced by naloxone-precipitated withdrawal jumping. Daily doses of an opiate sufficient to suppress abrupt withdrawal jumping in morphine-dependent animals may not necessarily maintain the animals' tolerance and physical dependence on morphine. The sites for the expression of acute opiate analgesia and withdrawal jumping are not those involved with the development of tolerance and physical dependence.

US$19.90

PMID: 7189707

DOI: 10.1016/0376-8716(80)90140-4


Other references

Sun, Y.; Zhang, Y-Jun.; Kong, X-Ming., 2015: No association of XRCC1 and CLPTM1L polymorphisms with non-small cell lung cancer in a non-smoking Han Chinese population. This study aimed to explore potential associations between single nucleotide polymorphisms (SNPs) of the x-ray repair cross-complementing group 1 (XRCC1) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) and non-small cell lung cance...

Jim, M-Hong.; Lee, M.Kang-Yin.; Fung, R.Chi-Yan.; Chan, A.Ka-Chun.; Chan, K-Tim.; Yiu, K-Hang., 2016: Six month angiographic result of supplementary paclitaxel-eluting balloon deployment to treat side branch ostium narrowing (SARPEDON). International Journal of Cardiology 187: 594-597

Hesling, J.J., 1972: Nematode pests of mushrooms. A useful account of the processes involved in commercial mushroom production is given with particular reference to the environments thus created for nematodes. Ditylenchus myceliophagus and Aphelenchoides composticola are the most serious nematode...

Maurin, M.; Raoult, D., 1993: Current concepts and perspectives in Q fever treatment. Raoult, D [Editor] Antimicrobial agents and intracellular pathogens : 155-179

Simon, Michael W., 1997: Five- vs 10-day treatment of acute otitis media with ceftibuten in infants and children. This study compared 5 and 10 days of ceftibuten in treatment of acute otitis media in 232 children 6 months to 14 years of age. Both groups received ceftibuten 9 mg/kg per day, to a maximum daily dose of 400 mg. Response to therapy was determined...

Elliott, JM., 1987: Population regulation in contrasting populations of trout Salmo trutta in two Lake District streams. (1) The chief objective was to compare the population dynamics of Salmo trutta L. in Wilfin Beck, populated only by resident brown trout, and in Black Brows Beck which serves as a nursery for the progeny of migratory trout (a mixture of sea and es...

Hartmann F.; Sahin U.; Engert A.; Pohl C.; Diehl V.; Thorpe P.; Senter P.; Pfreundschuh M., 1990: Hodgkins lymphoma specific targeting and prodrug activation by bispecific monoclonal antibodies. Journal of Cancer Research & Clinical Oncology 116(SUPPL PART 1): 324

Marin-Leon, L.; Francisco, P.Maria.Stolses.Bergamo.; Segall-Corrêa, A.Maria.; Panigassi, G., 2012: Household appliances and food insecurity: gender, referred skin color and socioeconomic differences. Data from the National Household Survey 2004 was analyzed to compare differences in prevalence among moderate or severe food insecurity. Also, it was compared food security or mild food insecurity households in relation to the assets and other soc...

Coughlan, B.; Sheehan, J.; Bunting, B.; Carr, A.; Crowe, J., 2004: Evaluation of a model of adjustment to an iatrogenic hepatitis C virus infection. The aim of this study was to evaluate a model of adjustment to an iatrogenic hepatitis C(HCV) infection in a cohort of women. Eighty-three women diagnosed with an iatrogenic HCV infection were recruited; 49 women had chronic infection (PCR positiv...

Liu, X.; Zhang, Z-Ren.; Fuller, M.D.; Billingsley, J.; McCarty, N.A.; Dawson, D.C., 2004: CFTR: a cysteine at position 338 in TM6 senses a positive electrostatic potential in the pore. We investigated the accessibility to protons and thiol-directed reagents of a cysteine substituted at position 338 in transmembrane segment 6 (TM6) of CFTR to test the hypothesis that T338 resides in the pore. Xenopus oocytes expressing T338C CFTR...