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Surface markers on primate b and t lymphoid cell lines identified by antibodies to human and simian lymphocyte antigens

, : Surface markers on primate b and t lymphoid cell lines identified by antibodies to human and simian lymphocyte antigens. Journal of Immunogenetics (Oxford) 9(4): 209-222

Simian B and T lymphoid cell lines maintain surface markers found on mature lymphocytes in vivo. The T lymphoid cell lines expressed Ia-like antigens on their surfaces, further suggesting that they represent mature, activated T cells. These Ia antigens show a structural similarity to Ia on human cells although some diversity exists. The Ia antigen expressed on T lymphoid cell lines was very similar to those on B lymphoid cell lines. Owl monkey and marmoset T lymphoid cell lines were also shown to express a VH [variable heavy chain] Ig-related determinant, a marker which is thought to be associated with T cell antigen receptor. Owl monkey and marmoset T cell lines express a surface antigen which identifies the sheep erythrocyte receptor on human T cells and some of these lines express an antigen found on human helper T cells. Substantial conservation of surface components has occurred within primate evolution such that monoclonal antibodies to human Ia, OKT-11a and Leu 3a markers can be used to type lymphocytes of lower primates.


PMID: 6181170

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