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Synthesis and properties of human beta endorphin 1 17 and its analogs


, : Synthesis and properties of human beta endorphin 1 17 and its analogs. International Journal of Peptide & Protein Research 19(4): 432-435

Four analogs of human .beta.-endorphin (.beta.h-EP) were synthesized by the solid-phase method: .beta.h-EP-(1-17) (I), [D-Ala2]-.beta.h-EP-1(1-17) (II), [Gln8]-.beta.h-EP-(1-17) (III) and [D-Ala2, Gln8]-.beta.h-EP-(1-17) (IV). Measurement in a radioreceptor binding assay [rat brain] with use of [3H].beta.h-EP as primary ligand gave relative potencies as follows: Met-enkephalin, 100; I, 33; II, 47; III, 889; IV, 123; .beta.h-endorphin, 2253.

US$29.90

PMID: 6288589


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