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Synthesis of 7 o trans 4' n substituted aminocyclohexanecarbonyldaunomycinone and adriamycinone and their in vitro antitumor activity


, : Synthesis of 7 o trans 4' n substituted aminocyclohexanecarbonyldaunomycinone and adriamycinone and their in vitro antitumor activity. Zhongguo Kanfshengsu Zazhi 10(4): 256-257

N-Formyl, N-acetyl, N-trifluoroacetyl, N-L-alanyl, N, N-dimethyl and N, N-dibenzyl derivatives of 7-O-(trans-4'-aminocyclohexanecarbonyl) daunomycinone and adriamycinone have been synthesized. They showed in-vitro antitumor activities against Hela cell and L1210 leukemia cell. Futhermore, N, N-dimethyl derivatives showed noticeable activities when bound to man-DNA and against L7712 leukemia cell in vitro.

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