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Synthesis of an analog of alpha msh 1 10 deca peptide as a substrate for enzymatic n alpha acetylation


, : Synthesis of an analog of alpha msh 1 10 deca peptide as a substrate for enzymatic n alpha acetylation. International Journal of Peptide & Protein Research 20(4): 289-297

The synthesis of a stable substrate for enzymatic N.alpha.-acetylation is described. To this end an analog of .alpha.-MSH-(1-10)-decapeptide with Nle instead of Met at position 4 is prepared. t-Butylation of an intermediate Z-Tyr-OMe leads only to .alpha. 75% conversion in a few hours' reaction time, and cannot be carried to completion. The [Nle4]-decapeptide is as good a substrate for enzymatic N.alpha.-acetylation as the original decapeptide containing Met.

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