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Synthesis of analogs of gamma aminobutyric acid xiv. synthesis and activity of unsaturated derivates of 5 aminopentanoic acid delta aminovaleric acid


, : Synthesis of analogs of gamma aminobutyric acid xiv. synthesis and activity of unsaturated derivates of 5 aminopentanoic acid delta aminovaleric acid. Australian Journal of Chemistry 38(11): 1651-1656

The (Z) and (E) pairs of 5-aminopent-2-enoic acid and 5-aminopent-3-enoic acid, as well as the related 5-aminopent-3-ynoic acid, have been prepared for structure-activity studies on GABA receptors. Only the (Z) isomers were active as GABA agonists with (Z)-5-aminopent-2-enoic acid being two- to four-fold more active than 5-aminopentanoic acid.

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