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Synthesis of analogs of gamma aminobutyric acid xiv. synthesis and activity of unsaturated derivates of 5 aminopentanoic acid delta aminovaleric acid

, : Synthesis of analogs of gamma aminobutyric acid xiv. synthesis and activity of unsaturated derivates of 5 aminopentanoic acid delta aminovaleric acid. Australian Journal of Chemistry 38(11): 1651-1656

The (Z) and (E) pairs of 5-aminopent-2-enoic acid and 5-aminopent-3-enoic acid, as well as the related 5-aminopent-3-ynoic acid, have been prepared for structure-activity studies on GABA receptors. Only the (Z) isomers were active as GABA agonists with (Z)-5-aminopent-2-enoic acid being two- to four-fold more active than 5-aminopentanoic acid.


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Gogineni, E.; Vargo, J.A.; Glaser, S.M.; Flickinger, J.C.; Burton, S.A.; Engh, J.A.; Amankulor, N.M.; Beriwal, S.; Quinn, A.E.; Ozhasoglu, C.; Heron, D.E., 2017: Long-Term Survivorship Following Stereotactic Radiosurgery Alone for Brain Metastases: Risk of Intracranial Failure and Implications for Surveillance and Counseling. Historically, survival for even highly select cohorts of brain metastasis patients selected for SRS alone is <2 yr; thus, limited literature on risks of recurrence exists beyond 2 yr. To investigate the possibility that for subsets of patients...

Zaragoza, A.A.; Catalá, M.; Colmena, M.L.; Valdemoro, C., 1999: Dental trauma in schoolchildren six to twelve years of age. The prevalence of dental injuries in Spanish children living in an urban area was studied in 4000 schoolchildren ages six to twelve years. A total of 227 children experienced dental injuries. Simple enamel fracture was the predominant injury (46.2...

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Nakagawa, K.; Tsugawa, N.; Okamoto, T.; Kishi, T.; Ono, T.; Kubodera, N.; Okano, T., 1999: Rapid control of transmembrane calcium influx by 1alpha,25-dihydroxyvitamin D3 and its analogues in rat osteoblast-like cells. 1alpha,25-Dihydroxyvitamin D3 [1alpha,25(OH)2D3] has been shown to exert both its nuclear vitamin D receptor (nVDR)-mediated genomic actions and membrane vitamin D receptor (mVDR)-mediated nongenomic actions. In this study, the effects of 1alpha,2...

Yu, S.-Mi; Oh, B.-Taek; Lee, Y.H.on, 2012: Biocontrol of green and blue molds in postharvest satsuma mandarin using Bacillus amyloliquefaciens JBC36. In order to control postharvest rot of satsuma mandarin (mandarin) fruits, a new strain of Bacillus amyloliquefaciens JBC36 (JBC36) was isolated from rhizosphere of a mandarin orchard and tested for its suppression of decay due to green and blue m...

Norambuena, M.C.cilia; Paredes, M., 2003: Variabilidad y estructura genetica en dos poblaciones de Vicugna vicugna (Camelidae) del norte de Chile. Two populations of Vicugna vicugna from regions First and Second of Chile were studied on the basis of the electrophoretic determination of 28 presumptive loci. Due to the phenotypic differences between the populations mentioned above, this kind o...