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Systemic metastases from medullo blastoma 2 cases and review of the literature

, : Systemic metastases from medullo blastoma 2 cases and review of the literature. Cancer 48(10): 2296-2306

The clinical and pathologic data from 2 cases of medulloblastoma with systemic metastases and 101 previously reported cases were evaluated to define better the clinical presentation and natural history. Patients ranged in age from 6 mo. to 48 yr with a mean of 13 yr; two thirds of the patients were male. Ventricular shunts had been inserted in 20% of the patients. Systemic metastases occurred on an average of 2 yr after the diagnosis of the primary tumor in patients without shunts but after only 1.3 yr in patients with shunts. Of the patients, 59% were known to have recurrence or spread of medulloblastoma within the CNS by the time systemic metastases appeared. Ninety percent showed radiologic evidence of bone metastases, of which 60% were osteoblastic, Bones most frequently involved were pelvis, femur and vertebrae; pain was the most common initial symptom. At autopsy lymph nodes metastases were found in 65% and liver metastases were found in 28% of all cases in addition to bone metastases in 82%. Lung metastases occurred in 9% of the patients without shunts, compared with 30% of patients with shunts. The average survival was 7 mo. after the appearance of systemic metastases for patients with and without shunts. Approximately 5% of patients with medulloblastoma may be expected to develop systemic metastases. This development is associated with increased mobidity and a shortened life expectancy.


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Aldrin, M.; Lyngstad, T.M.; Kristoffersen, A.B.; Storvik, B.; Borgan, Ø.; Jansen, P.A., 2012: Modelling the spread of infectious salmon anaemia among salmon farms based on seaway distances between farms and genetic relationships between infectious salmon anaemia virus isolates. Infectious salmon anaemia (ISA) is an important infectious disease in Atlantic salmon farming causing recurrent epidemic outbreaks worldwide. The focus of this paper is on tracing the spread of ISA among Norwegian salmon farms. To trace transmissi...

Friedman H.S.; Vasavada B.C.; Jubay F.; Sacerdote A.; Bleicher S.J.; Bandu I., 1981: Pathogenesis of diabetic cardio myopathy a proposal. Clinical Research 29(2): 192A

Nakaya, H.; Tsuruta, K.; Yoshimura, N., 2010: Study on the cross-sectional variability of bedload discharges in a mountain stream. Sediment transport measurements in mountain torrents are pivotal to comprehend the nature of the process. Long-term continuous measurement in natural river basins with a substantial scale has been circumvented by many obstacles. Direct sampling, t...

Russell, J.A.; Leng, G., 2002: Ready to burst?. Journal of Neuroendocrinology 14(12): 927-928, December

Haragopal, T.; Nayudu, M.V., 1971: A new sap transmissible Groundnut chlorotic spot virus. Symptoms of the disease, noted frequently in fields around Tirupati for about 4 yr, were chlorotic leaf spots, some developing into ringspots, vein clearing on young terminal leaves of young axillary shoots and eventually a faint, even mottle. The...

Frauenfelder, H.; Gratton, E., 1986: Protein dynamics and hydration. Methods in Enzymology 127: 207-216

Kanakova N.I.; Ugodchikov G.A.; Nelyubin A.S., 1981: Use of total systems analysis for the mathematical modeling of bacterial biomass growth with regard to the effect of lipid per oxidation. A mathematical total systems analysis model of batch cultivation of Escherichia coli which considers the processes of lipid peroxidation was formulated and tested for adequacy. The model is adequate for the transitory processes of batch cultivatio...

D.B.ri, M.; Salti, F.; Nardi, M.; Pahor, M.; D.F.sco, C.; Tonon, E.; Ungar, A.; Pini, R.; Masotti, G.; Marchionni, N., 1999: Undertreatment of hypertension in community-dwelling older adults: a drug-utilization study in Dicomano, Italy. Objective: To define: (1) the prevalence of and (2) factors associated with undertreatment of hypertension in older persons; and (3) the prevalence of specific drug regimens and reasons for their selection. Participants: Cross-sectional survey of...

Radvany P.; Weinstein K.B.; Spadaro J.; Fishbein M.; Bing O.H.L., 1978: Hypertrophy of noninfarcted myo cardium following experimental coronary artery occlusion. Circulation Supplement 58(2): II-224

Djurić, D.; Drndarević, V.; Vujić, D., 1999: Microprocessor-controlled freezing device for cryopreservation of cell samples. A freezing device for cryopreservation of blood mononuclear cells has been developed. The device is microcontroller operated, allowing cell freezing by a fully automatic, unattended process. To ensure optimum preservation, the temperature in the c...