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Temporal changes in serum androgen after temporary impairment of leydig cell function by ethane 1 2 di methanesulfonate


, : Temporal changes in serum androgen after temporary impairment of leydig cell function by ethane 1 2 di methanesulfonate. Journal of Steroid Biochemistry 10(4): 467-470

The administration of ethane-1,2-dimethane sulfonate (EDS) 75 mg/kg to adult male rats produced a decrease in serum androgen level for up to 7 wk. The maximum suppression of serum androgen, comparable to castration, was seen 24 h after administration followed by a gradual return to control levels at 7 wk. Castration-like changes occurred in the ventral prostate and epididymis associated with testicular weight loss. Testis and ventral prostate weight but not epididymal weight had recovered by wk 7. EDS, a simple diester of methane sulphonic acid is a non steroidal antifertility agent.

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