+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Testicular function in type II hyperlipoproteinemic patients treated with lovastatin (mevinolin) or neomycin

, : Testicular function in type II hyperlipoproteinemic patients treated with lovastatin (mevinolin) or neomycin. Journal of Clinical Endocrinology and Metabolism 65(3): 546-550

Steroid synthesis requires cholesterol derived from de novo synthesis or plasma lipoproteins. Low density lipoproteins appear to be the major contributor of cholesterol for steroid synthesis in man. Patients with disorders of low density lipoproteins or the low density lipoprotein receptor have reduced cortisol production in response to ACTH. Therapeutic agents designed to lower plasma cholesterol could, therefore, adversely affect steroid hormone production. Lovastatin (mevinolin) is a new hypolipidemic agent which blocks cholesterol synthesis by competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. In beagle dogs, lovastatin at 40-180 times the clinically effective dose in man, has been associated with an increase in spontaneous testicular atrophy. Accordingly, the effect of lovastatin on testicular function and lipoprotein levels was studied in 16 hyperlipidemic men in a randomized, double blind, cross-over study with another hypolipidemic agent, neomycin. Serum testosterone, PRL, LH, and FSH; LHRH-stimulated LH and FSH concentrations; and testicular size were measured, and semen analyses were made. We found no evidence that lovastatin had adverse effects on testicular function despite significant alterations in plasma lipoprotein concentrations.


PMID: 3114306

DOI: 10.1210/jcem-65-3-546

Other references

Anonymous, 1973: Annual Report on research and technical work of the Ministry of Agriculture for Northern Ireland 1972. (continued). a. In the Plant Path. Res. Div. (R.K.McKee, 123-132) the production of disease free cereal seed was studied and tests with thiram soaks on numerous oat cvs. proved successful.b. As in 1971, the incidence of mildew (Erysiphe graminis) in barley plo...

Davis, J.S.; Karpook, E.J., 1999: A review of airborne, soil, and subaerial algae in Florida. Algae of the three habitats are mostly unicellular chlorophytes and cyanophytes, but chrysophycean, diatom, and euglenoid taxa are often well represented. Earlier studies were concerned with identification of the organisms in relation to specific...

Petit-Cocault, L.; Volle-Challier, Cécile.; Fleury, M.; Péault, B.; Souyri, Mèle., 2007: Dual role of Mpl receptor during the establishment of definitive hematopoiesis. Cytokine signaling pathways are important in promoting hematopoietic stem cell (HSC) self-renewal, proliferation and differentiation. Mpl receptor and its ligand, TPO, have been shown to play an essential role in the early steps of adult hematopo...

Alvarez, M.J.; Díez, A.; López-Bote, C.; Gallego, M.; Bautista, J.M., 2001: Short-term modulation of lipogenesis by macronutrients in rainbow trout (Oncorhynchus mykiss) hepatocytes. Rainbow trout (Oncorhynchus mykiss) hepatocytes were cultured under simulated conditions of varying nutritional status to explore the short-term modulation by dietary substrates of the main lipogenic enzymes: glucose-6-phosphate dehydrogenase (G6P...

Rasker, R., 1992: Dynamic economy versus static policy in the greater yellowstone ecosystems. General technical report SE US Department of Agriculture Forest Service Southeastern Forest Experiment Station: (78) 201-216

Wojtowicz; Kolesnik; Miotkowski; Furdyna, 1993: Magnetization of bound magnetic polarons: Direct determination via photomemory effect. Physical Review Letters 70(15): 2317-2320

Peiperl, L.; Sande, M.A., 1994: Tuberculosis and human immunodeficiency virus disease. Western Journal of Medicine 160(3): 252-253

Armstrong, D., 1973: Pasture weed control. MCPA at 0.25-0.5 lb/acre, applied in May-June (autumn) is recommended for the control of buttercups (Ranunculus spp.) in pastures; the rate should be increased to 0.75 lb/acre to control R. acris. A follow-up spray in spring with MCPB (to avoid cl...

Giebułtowicz, J.; Wolinowska, R.; Sztybor, A.; Pietrzak, M.; Wroczyński, P.; Wierzchowski, J., 2009: Salivary aldehyde dehydrogenase: activity towards aromatic aldehydes and comparison with recombinant ALDH3A1. A series of aromatic aldehydes was examined as substrates for salivary aldehyde dehydrogenase (sALDH) and the recombinant ALDH3A1. Para-substituted benzaldehydes, cinnamic aldehyde and 2-naphthaldehydes were found to be excellent substrates, and k...

Kamel, R.; Mahmoud, A.; El-Feky, G., 2012: Double-phase hydrogel for buccal delivery of tramadol. Treatment of chronic pain is complicated by the evidence that abuse of prescription opioids is rising; therefore, in many cases, chronic pain remains undertreated. Tramadol is an atypical central analgesic with a mixed mechanism of action offering...