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The activity of rat brain j and d forms of glycogen synthase under the effect of natural physiological stimulants and cyclic 3' 5' amp

, : The activity of rat brain j and d forms of glycogen synthase under the effect of natural physiological stimulants and cyclic 3' 5' amp. Biologicheskii Zhurnal Armenii 34(8): 801-806

Intracisternal injection of cAMP (15 min and 30 min before the experiments) to rats inhibits the activity of brain J-form glycogen synthase. Injection of cAMP to rats 30 min before the experiment with food stimulation increases the activity of J-form glycogen synthase in comparison with the enzyme activity of rats with the same functional conditions of the brain, but the injection of cAMP was 15 min before the experiment. Injection of cAMP (15 min before the experiment) to rats with conditioned food inhibition did not prevent the effect of this functional state.


Other references

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Ohnishi, A.; Senda, M.; Yamane, T.; Sasaki, M.; Mikami, T.; Nishio, T.; Ikari, Y.; Nishida, H.; Shukuri, M.; Takashima, T.; Mawatari, A.; Doi, H.; Watanabe, Y.; Onoe, H., 2015: Human whole-body biodistribution and dosimetry of a new PET tracer, [(11)C]ketoprofen methyl ester, for imagings of neuroinflammation. Neuroinflammatory processes play an important role in the pathogenesis of Alzheimer's disease and other brain disorders, and nonsteroidal anti-inflammatory drugs (NSAIDs) are considered therapeutic candidates. As a biomarker of neuroinflammat...