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The atropine resistant component of the neurogenic response of the rabbit urinary bladder


, : The atropine resistant component of the neurogenic response of the rabbit urinary bladder. European Journal of Pharmacology 99(4): 295-302

Rabbit bladder body was stimulated to contract by a number of agonists, of which bradykinin was the most potent, and ATP one of the least potent substances tested. The atropine-resistant component of the neurogenic response was unaffected by 2 .times. 10-5 M chlorpheniramine or 10-6 M methysergide, doses which suppressed responses to histamine or 5HT [5-hydroxytryptamine]. Indomethacin 10-5 M, or 10-5 M capsaicin both reduced the atropine-resistant component. Following treatment with 10-6 M atropine and 10-5 M indomethacin or 10-6 M prazosin, 10-4 M ANAPP3 [arylazidoaminopropionyl ATP] produced a further suppression of the response, but did not antagonize the response to ATP. In the bladder body, the transmitter(s) responsible for the neurogenic response may be acetylcholine and prostaglandins and possibly ATP and substance P.

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Other references

Kangas, E., 1978: Mordellistena carinthiaca new record new for finland and sweden coleoptera mordellidae. M. carinthiaca Erm., previously known only from Austria, is reported from southwestern Finland and Scania, Sweden.

Cipollone, J.A.; Graves, M.L.; Köbel, M.; Kalloger, S.E.; Poon, T.; Gilks, C.Blake.; McNagny, K.M.; Roskelley, C.D., 2012: The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma. High grade serous ovarian tumors often metastasize transperitoneally, a process that begins when small tumor nodules de-adhere and are released into the fluid of the abdominal cavity where they float freely to reach new sites on the peritoneal wal...

Campbell, D.A.; Manders, E.K.; Oehler, J.R.; Bonnard, G.D.; Oldham, R.K.; Herberman, R.B., 1977: Inhibition of in vitro lymphoproliferative responses by in vivo passaged rat 13762 mammary adenocarcinoma cells. I. Characteristics of inhibition and evidence for an infectious agent. Cellular Immunology 33(2): 364-377

Narang, U.; Bhardwaj, R.; Garg, S.K.; Thukral, A.K., 2011: Phytoremediation of mercury using Eichhornia crassipes Mart Solms. Roots of Eichhornia crassipes were found to accumulate maximum content of mercury (92.21 μg g<SUP align=right>−1</SUP> dry wt) in the roots of plants treated with 1 μg l<SUP align=right>−1</SUP> concentrat...

Anonymous, 1976: Harvesting raspberries by machine. Raspberry canes for mechanical harvesting are bent over and outwards horizontally in the winter, and the fruits are borne on short upright laterals. The mechanical shaker/harvester described requires 6 men to operate and can harvest 900 kg/h. Mech...

Schwab, S., J.; Weiss, M., A.; Rushton, F.; Ross, J., P.; Jackson, J.; Kapoian, T.; Yegge, J.; Rosenblatt, M.; Reese, W., J.; Soundararajan, R.; Work, J.; Ross, J.; Stainken, B.; Pedan, A.; Moran, J., A., 2002: Multicenter clinical trial results with the LifeSite(R) Hemodialysis Access System. Background: The LifeSite(R) Hemodialysis Access System is a subcutaneous access device designed to maximize blood flow while minimizing access-related complications. The purpose of this study was to compare the efficacy and safety of the LifeSite...

Chan, F.Ka-Ming.; Shisler, J.; Bixby, J.G.; Felices, M.; Zheng, L.; Appel, M.; Orenstein, J.; Moss, B.; Lenardo, M.J., 2003: A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. Members of the tumor necrosis factor (TNF) receptor (TNFR) superfamily are potent regulators of apoptosis, a process that is important for the maintenance of immune homeostasis. Recent evidence suggests that TNFR-1 and Fas and TRAIL receptors can...

Aker, S.N.; Cheney, C.L., 1983: The use of sterile and low microbial diets in ultraisolation environments. The evidence for the use of sterile and low-microbial diets in ultraisolation environments is reviewed. Studies have suggested that sterile food is not required for gut sterilization when oral nonabsorbable antibiotics are used, but if a low micro...

Gu, W.; Zhao, H.; Yenari, M.A.; Sapolsky, R.M.; Steinberg, G.K., 2004: Catalase over-expression protects striatal neurons from transient focal cerebral ischemia. Reactive oxygen species (ROS) play key roles in the cascade of brain injury after stroke, and strategies to increase the antioxidant defenses of neurons after stroke hold great promise. In this study we evaluate the neuroprotective potential of us...

Moss, R.A.; Tian, J.; Sauers, R.R.; Sheridan, R.S.; Bhakta, A.; Zuev, P.S., 2005: Kinetic studies of the cyclization of singlet vinylchlorocarbenes. [reaction: see text] Vinylchlorocarbenes (R = Me or Cl) cyclize to cyclopropenes with k = (2.4-5.1) x 10(7) s(-1) or (3.1-4.5) x 10(6) s(-1), respectively, in solution at room temperature. The corresponding E(a) values are 6.6 and 5.7 kcal/mol. Ex...