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The atropine resistant sacral parasympathetic vascular and motility responses in the cat colon


, : The atropine resistant sacral parasympathetic vascular and motility responses in the cat colon. Journal of Physiology (Cambridge) 311: 421-430

Pelvic nerve stimulation in atropinized cats elicits a sustained contraction of the proximal colon and a relaxation of the rectum. Concomitantly, there is an immediate but transient vasodilatation which is followed by recurrent increases and a slight poststimulatory hyperemia. Direct stimulation of the pelvic nerve produces secretion of colonic kallikrein and activation of the plasma kinin system. Trasylol, which inhibits the kinin system, is studied to determine whether it affects the atropine-resistant responses observed on pelvic nerve stimulation. After i.v. or close intraarterial administration of Trasylol, the initial vasodilatation on pelvic nerve stimulation was markedly reduced and in a few experiments completely blocked. The recurrent blood flow increases and the poststimulatory hyperemia observed on prolonged stimulation were completely abolished. The proximal colonic contraction and the rectal relaxation appeared unchanged after Trasylol. The reactivity of the vascular bed after Trasylol injection was studied by recording the changes of vascular resistance following sympathetic vasoconstrictor fiber activation and infusion of bradykinin before and after Trasylol injection. The responses were quantitatively unchanged excluding an unspecific interference with nervous transmission or vascular smooth muscle reactivity. The atropine-resistant vasodilatation in the cat colon as elicited by pelvic nerve stimulation is apparently partly abolished by a kallikrein inhibitor. Kinins might be involved in this response. The motor response apparently is not dependent on such a mechanism.

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