+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effect of glucagon and th glucagon on steroid metabolism in isolated rat hepatocytes

, : The effect of glucagon and th glucagon on steroid metabolism in isolated rat hepatocytes. Molecular & Cellular Endocrinology 55(2-3): 203-208

Glucagon decreases the activity of steroid-metabolising enzymes in isolated rat liver cells at physiological concentrations. Higher concentrations are less effective. TH-glucagon (1-N-.alpha.-trinitrophenylhistidine-12-homoarginine-glucagon) also reduces enzyme activity but does not lose activity at higher concentrations. The effects of the two hormones mimic closely their reported effects on phosphatidylinositol-4,5-bisphosphate breakdown. It is, thus likely that the effect of glucagon on steroid metabolism is mediated via breakdown of this phospholipid. The calcium ionophore, A23187, had no effect on steroid metabolism whereas the phorbol ester 4.beta.-phorbol-12-myristate-13-acetate (PMA) mimicked the effect of glucagon, showing that activation of protein kinase C but not Ca2+ mobilization may be involved in glucagon's action on hepatic steroid metabolism.


PMID: 3128458

Other references

Sapirstein, L.A.; Brandt, W.; Drury, D.R., 1950: Effect of adrenalectomy on salt hypertension. Fed Proc 9(1): 112

Gupta, N.; Dudding, N.; Crossley, J.; Payyappilly, S.J.; Smith, J.H.F., 2013: Outcome of SurePath™ cervical samples reported as borderline nuclear change by cytological subtype and high-risk HPV status. N. Gupta, N. Dudding, J. Crossley, S.J. Payyappilly and J.H.F. Smith Outcome of SurePath cervical samples reported as borderline nuclear changes by cytological subtype and high-risk HPV status The average borderline rate in cervical cytology sampl...

Kolber, Z.; Zehr, J.; Falkowski, P., 1988: Effects of Growth Irradiance and Nitrogen Limitation on Photosynthetic Energy Conversion in Photosystem II. Photosynthetic energy conversion was investigated in five species of marine unicellular algae, (Dunaliella tertiolecta, Thalassiosira pseudonana, T. weisflogii, Skeletorema costatum, Isochrysis galbana) representing three phylogenetic classes, whi...

Bryant D.T.W.; Smith R.W., 1982: Protein synthesis in muscle of mature sheep. Protein synthesis was measured in wether sheep by constant i.v. infusion of [3H]tyrosine. The specific radioactivity of plasma tyrosine at plateau was used to calculate tyrosine flux and the rate of protein synthesis in the whole body was estimate...

dos Santos Raimundo Oliver Brasil; Costa Joao Batista Sena, 1995: The structure of the northern Araguaia Belt in the Xambioa region, Sao Geraldo do Araguaia. Geociencias (Sao Paulo) 14(2): 207-225

Nossent, J.C.; Bronsveld, W.; Swaak, A.J., 1989: Systemic lupus erythematosus. III. Observations on clinical renal involvement and follow up of renal function: Dutch experience with 110 patients studied prospectively. A prospective study of 110 patients with systemic lupus erythematosus (SLE) was undertaken to evaluate the reliability of clinical signs of lupus nephritis, which developed in 39 (35%) patients. Those patients with SLE who showed no clinical signs...

Roth, D.M.; Senna, J.P.M.; Machado, D.C., 2006: Evaluation of the humoral immune response in BALB/c mice immunized with a naked DNA vaccine anti-methicillin-resistant Staphylococcus aureus. Methicillin-resistant Staphylococcus aureus (MRSA) is the major pathogen involved in nosocomial infections, leading to high rates of morbidity and mortality in hospitals worldwide. The methicillin resistance occurs due to the presence of an addit...

Ben-Ishay, D.; Viskoper, R.J.; Menczel, J., 1972: Effect of spironolactone on urinary calcium excretion. Israel Journal of Medical Sciences 8(4): 495-501

Velasco Suarez, C., 1963: Personal technic for the fixation of the Kehr tube. Boletines Y Trabajos - Sociedad de Cirugia de Buenos Aires 47: 329-330

Vlasov, T.D.; Chefu, S.G.; Baĭsa, A.E.; Leko, M.V.; Burov, S.V.; Veselkina, O.S., 2011: Amides of creatine: perspectives of neuroprotection. We evaluated the efficacy of derivatives of creatine and amino acids (CrAA) for decreasing cerebral injury in rats with transient middle cerebral artery occlusion (MCAO). Neuroprotective effects of amides of creatine and glycine (CrGlyOEt), phenyl...