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The effect of selected anti neoplastic agents on the morphology of candida albicans 5865


, : The effect of selected anti neoplastic agents on the morphology of candida albicans 5865. Canadian Journal of Microbiology 26(7): 812-818

When examined in an amino acid-supplemented inorganic salts-glucose medium, the morphological development of C. albicans 5865 is inhibited or delayed by several drugs common to cancer chemotherapy protocols. Yeast phase growth is inhibited by actinomycin D (100 .mu.g/ml), bleomycin (500 .mu.g/ml), 5-fluorouracil (1000 .mu.g/ml) and hydroxyurea (1000 .mu.g/ml). Germ tube formation was also inhibited by actinomycin D (100 .mu.g/ml) and vincristine (100 .mu.g/ml), doxorubicin and bleomycin (each at 500 .mu.g/ml) and 5-fluorouracil, cycloheximide, hydroxyurea and vinblastine at 1000 .mu.g/ml, respectively. Following a 3 h exposure to the above drugs supplemented with sublethal concentrations of amphotericin B (AMB), yeast germination and chlamydospore formation were delayed 60-96 h. Culturing yeasts for 24 h in the presence of both AMB and actinomycin D resulted in a 90% loss in viability. Two antimetabolites not common to chemotherapeutic protocols also showed fungistatic and fungicidal activity. At 24 h, pentamidine isethionate (100 .mu.g/ml) alone had a 90% kill rate which increased to greater than 99.99% when combined with AMB. A cyclic hydroxaneic acid, 7-chloro-3,4-dihydro-1-hydroxycarbostyril (7-Cl ADHC), demonstrated the lowest minimum germ tube inhibitory concentration (1 .mu.g/ml). A 90% kill rate was obtained after culturing yeasts for 24 h in 7-Cl ADHC (100 .mu.g/ml) supplemented with AMB.

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