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The effects of chronic cobalt exposure on passive avoidance performance in the adult rat


, : The effects of chronic cobalt exposure on passive avoidance performance in the adult rat. Bulletin of the Psychonomic Society 23(6): 527-530

Adult male rats were tested for acquisition and retention of step-down passive avoidance following exposure to either distilled water contaminated with cobalt chloride (Group Cobalt) or uncontamined distilled water (Group Control). Exposure to 20 mg cobalt/kg body weight per day, for 57 days, produced significantly greater step-down passive-avoidance latencies during retention testing in Group Cobalt relative to controls. Analyses of passive-avoidance-acquisition data, analgesic-tolerance test results, and body weights produced no significance group differences. Significant accumulations of cobalt were detected in blood, brain, and left testis of treated animals.

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