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The effects of parenteral injections of adenosine and its analogs on blood pressure and heart rate in the rat

, : The effects of parenteral injections of adenosine and its analogs on blood pressure and heart rate in the rat. General Pharmacology 18(4): 405-416

1. The dose-response effects of adenosine and its analogs on cardiovascular parameters were examined in rats following intravenous administration. 2. 5'-N-ethylcarboxamidoadenosine (NECA) was by far the most potent analog in reducing mean arterial blood (PA) pressure while N6-(3-pentyl)-adenosine exerted the most potent bradycardic action. 3. The N6-substituted (S)-diastereoisomers were substantially less potent in reducing PA and heart rate than NECA and the N6-substituted (R)-diastereoisomers. 4. The cardiovascular effects of adenosine analogs persist, to varying degrees, much longer than those of adenosine itself.


PMID: 3038667

DOI: 10.1016/0306-3623(87)90099-1

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