geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effects of the systemic administration of n methylmorphine chloride a quaternary analogue of morphine that does not cross the blood brain barrier on the release of anterior pituitary hormones in the rat


, : The effects of the systemic administration of n methylmorphine chloride a quaternary analogue of morphine that does not cross the blood brain barrier on the release of anterior pituitary hormones in the rat. Psychoneuroendocrinology 12(1): 67-72

The acute administration of morphine elicits changes in the release of anterior pituitary hormones. The locus of this action is thought to be in the cental nervous system, specifically the hypothalamus. There are some data suggesting that systemically administered opiates and opioid peptides can act outside of the blood-brain barrier to influence anterior pituitary hormone release. To test this hypothesis we examined the effects of the systemic administration of N-methylmorphine chloride, a quaternary analogue of morphine that does not cross the blood-brain barrier, on the release of corticosterone, growth hormone, prolactin, luteinizing hormone, and thyroid stimulating hormone in the rat. N-methylmorphine caused increases in the release of growth hormone and prolactin, but serum levels of corticosterone, luteinizing hormone and thyroid stimulating hormone were unaffected. These results indicate that the opiate-induced release of growth hormone and prolactin may be mediated in part by sites outside of the blood-brain barrier.

US$29.90

PMID: 3035598


Other references

Ciobanu, L.; Cozma, C.Dima.; Turcanu, D., 2005: Left cardiac dysfunction in COPD. The study of evaluation and rehabilitation of COPD patient (SERBOC) started in January 2004 in the 6th Medical Clinic of the Iaşi Rehabilitation Hospital. One of its goals is to evaluate the left cardiac morphology and function in the chronic obs...

Marcangione, C.; Constantin, A.; Clarke, P.B.S., 2011: Lack of effect of dopaminergic denervation on caudate-putamen hyperthermia or hypothermia induced by drugs and mild stressors. A number of drugs and psychological stressors induce brain hyperthermia and increase extracellular dopamine in the caudate-putamen. The present study tested whether caudate-putamen hyperthermia produced by such stimuli is dependent on dopaminergic...

Yalegama, L.L.W.C.; Chavan, J.K., 2006: Studies on utilization of coconut flour as a source of cell wall polysaccharides. The objectives of this study were: to determine the composition of coconut flour; to standardize the methods for isolation of food grade fibre from fresh coconut kernel; and to utilize coconut fibre in cookie preparation. Coconut flour was obtaine...

Summers, J.D.; Blackman, S.; Leeson, S., 1988: A simplified diet for assaying methionine activity. Several experiments were undertaken to evaluate diets that could be used to bioassay methionine activity in various compounds. The following semipurified diets were tested: a corn-soy-gelatin basal (CSG) diet supplemented with essential amino acid...

Husebekk A., 1991: The serum level of c reactive protein gives valuable information in patients with all kinds of inflammatory conditions. C-reactive protein (CRP) is a characteristic inflammation marker. In healthy individuals the serum concentration of CRP is less than 10 mg/l. With serious inflammation the serum concentration may increase to more than 1,000 fold. With few exceptio...

Hagihara, S.; Nakatani, K.; Saito, I., 2003: Recognition of DNA mismatch structures. A dimeric form of 2-amino-1,8-naphthyridine strongly binds to a G-G mismatch by a zigzag intercalation. To gain insight into the mode of recognition for the G-G mismatch, we have synthesized a series of naphthyridine-heterocycle hybrids and evalua...

Auber, J., 1956: Le Parc National du Niokolo-Koba. XII. Myrmeleonides. Memoires de l'Institut Francais d'Afrique Noire Dakar, no. 48: 209-210

Yang, Y.L.; Ding, Y.; Ding, D.S., 1996: The effect of air purification on 10,000 degree clean room in supply rooms. This article introduced that purifying equipments were installed in the major operating departments of supply rooms in hospital, and that experimental tests were done on the packing department. In statil state, the air humidity and the number of b...

Gilchrist, R.B.; Luciano, A.M.; Richani, D.; Zeng, H.T.; Wang, X.; Vos, M.De.; Sugimura, S.; Smitz, J.; Richard, F.J.; Thompson, J.G., 2016: Oocyte maturation and quality: role of cyclic nucleotides. The cyclic nucleotides, cAMP and cGMP, are the key molecules controlling mammalian oocyte meiosis. Their roles in oocyte biology have been at the forefront of oocyte research for decades, and many of the long-standing controversies in relation to...

Kamel, S.H.; Ezzat, E.A., 1969: Studies on blood transfusion in dogs. Zentralblatt für Veterinarmedizin. Reihe A 16(8): 720-722