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The influence of food on the absorption of diclofenac after single and multiple oral doses

, : The influence of food on the absorption of diclofenac after single and multiple oral doses. European Journal of Clinical Pharmacology 19(1): 33-38

A single dose of enteric-coated diclofenac [antiinflammatory analgesic] sodium was taken fasting and immediately after a standard breakfast by 12 healthy volunteers. A considerable delay in the onset of absorption was observed, non-fasting, varying from 2.5-12 h compared with 1.5-2.75 h when fasting. Peak plasma concentrations were reduced after food but areas under plasma concentration-time curves were comparable. Six subjects then took part in a study involving single and repeated dosing under fasting and nonfasting conditions. Prolonged and variable delays were observed when the enteric-coated tablets were taken after food. On repeated dosing, maximum plasma concentrations were reached after 6 h non-fasting compared with 2.5 h fasting. Peak plasma levels were similar.


PMID: 7461021

DOI: 10.1007/bf00558380

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