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The influence of thymosterin b on the number of leukocytes in the peripheral blood of rats irradiated with x rays

, : The influence of thymosterin b on the number of leukocytes in the peripheral blood of rats irradiated with x rays. Revue Roumaine de Medecine Endocrinologie 20(3): 177-180

Thymosterin B, a fat-soluble extract isolated from calf thymus, was administered to male Wistar rats to determine its leukopoietic effects. The leukocyte count in the experimental and control groups was lowered by irradiation with X-rays. Blood extracted from the tail 24 h after irradiation showed decreases in the number of leukocytes of 66% and 65%, respectively. Samples taken 9 days after irradiation showed an increase in the number of leukocytes for both groups, but only the increase for the experimental group, which had received 5 s.c. injections of thymosterin B, was statistically significant. There was no significant difference between the 2 groups in the number of lymphocytes. Thymosterin B may thus be concluded to have a radioprotective effect due to its stimulation of leukopoiesis.


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