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The Manx cat: an animal model for neural tube defects

, : The Manx cat: an animal model for neural tube defects. Materia Medica Polona. Polish Journal of Medicine and Pharmacy 19(4): 219-221

Basic knowledge about the aetiology and pathogenesis of spina bifida and other neural tube defects in man is lacking. The Manx cat is a tail-less variant of the common domestic cat which exhibits a heritable form of neural tube defect which can present with a broad spectrum of clinical pictures, including spina bifida. A kindred of Manx cats is presented here in which some individuals were conceived and born in the Isle of Man, and others were conceived and born in the West of Scotland. The pedigree of the kindred suggests that the overwhelmingly important factor in the production of the tail-less, or "Manx" trait, is a single autosomal dominant gene for the trait, and it is suggested that the Manx cat may be a suitable animal model for studies into the aetiology and pathogenesis of spina bifida and other neural tube defects.


PMID: 3454827

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