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The mechanism of cerebral hyperexcitability after irradiation

, : The mechanism of cerebral hyperexcitability after irradiation. International Journal of Radiation Biology & Related Studies in Physics Chemistry & Medicine 46(4): 421-424

Whole-body irradiation at a lethal dose induced an early and transient perturbation of 3H-Muscimol specific binding in the mouse cerebellum. The density of high affinity binding sites was decreased and was associated with a increased affinity. This effect can explain early radio-induced cerebral hyperexcitability. Previous injection of cysteamine, which protects against cerebral hyperexcitability, also offers a good protection against this effect.


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