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The mixed salivary gland tumor a normally benign human neoplasm frequently showing specific chromosomal abnormalities


, : The mixed salivary gland tumor a normally benign human neoplasm frequently showing specific chromosomal abnormalities. Cancer Genetics & Cytogenetics 2(3): 231-242

Using banding techniques, 10 pleomorphic adenomas were studied in preparations from primary cultures. Forty percent of the tumors had 1 or more abnormal stem lines. Two benign mixed tumors showed an identical and reciprocal 3;8 translocation. A 3rd adenoma, with signs of early malignant transformation, had a 3p- marker and a 8p-q- marker with break points close to those found in the 2 cases with identical 3;8 translocation. The 4th adenoma with an abnormal stem line contained as many as 8 different markers in its stem line karyotype. Several, possibly many, karyotypic evolutionary pathways exist in pleomorphic adenomas. The results are discussed in relation to the previously existing sparse data availabe on mixed tumors and in relation to the possible general significance of chromosome changes affecting no. 3 and 8.

US$19.90

DOI: 10.1016/0165-4608(80)90030-8


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