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The oral immune system: dynamics of salivary immunoglobulin production in the inbred mouse

, : The oral immune system: dynamics of salivary immunoglobulin production in the inbred mouse. Immunological Investigations 15(4): 339-349

In the oral cavity, salivary immunoglobulins (Igs) are the principal mediators of specific immunity. Using carbachol to stimulate saliva flow, we investigated, in a kinetic study, individual variations in salivary Ig concentrations in 23 adult BALB/c mice using an enzyme-linked immunosorbant assay (ELISA). It appeared that salivary Ig concentrations are highly variable in individual mice (IgA: 3-81 micrograms/mL; IgG: 0-2.9 micrograms/mL; IgM: 0.002-0.14 microgram/mL). In individual mice stimulated at different times over a 3 week period there are considerable variations both in salivary Ig concentrations and in their respective ratio. Broad variations were also found in the levels of specific IgA and IgG antibodies to three indigenous oral murine bacteria. Present data thus indicate that among genetically identical mice of the same age and sex, sharing identical diet, there is considerable heterogeneity in salivary Igs. As this heterogeneity was mimicked at the cellular level in major and minor salivary gland-associated B-cells, it appears that antibody dynamics in the oral cavity could reflect the adaptive capacity of the oral immune system to local antigenic challenge.


PMID: 3093375

DOI: 10.3109/08820138609052953

Other references

Palmer, E.D., 1949: Clinical observations on the behavior of foreign bodies in the stomach. Review of Gastroenterology 16(4): 349-356

Presl, J.; Kielland, C.C., 1975: 60-years of Kielland's forceps. Ceskoslovenska Gynekologie 40(10): 757-758

Wajdi, N., 1968: Studies on the larval development of Schistosoma mansoni in different species of snails hosts. Bulletin of Endemic Diseases 10(1): 134-146

Klein, S.; Patzkéwitsch, D.; Reese, S.; Erhard, M., 2016: Effects of socializing piglets in lactation on behaviour, including tail-biting, in growing and finishing pigs. The aim of this study was to determine whether early socialising of piglets influences the later behaviour and the risk of tail biting in growing and finishing pigs. The behaviour of 183 animals (divided in three successive runs) was recorded from...

Mueller Cohrs J., 1991: An improvement of the westlake symmetric confidence interval. A common statistical method for assessing bioequivalence of two formulations of a chemical substance is the symmetric confidence interval of WESTLAKE (1972). As mentioned by WESTLAKE (1981) and SCHUIRMAN (1981) a more powerful method consists of t...

Kahn, D.; Hobson, J.Allan., 2005: State-dependent thinking: a comparison of waking and dreaming thought. Thinking is known to be state dependent but a systematic study of how thinking in dreams differs from thinking while awake has not been done. The study consisted of analyzing the dream reports of 26 subjects who, in addition to providing dream rep...

Westby, S.; McGinty, F.; Carr, I., 1976: A quantitative microscopical study of tumour cell nuclei in lymphatic metastasis, using a Quantimet. The projected areas of nuclei of tumour cells in experimental and human tumours have been measured with a Quantimet. In nearly all the specimens examined the nuclei in the lymph node metastasis, and the nuclei in the site from which metastasis had...

Abbasi, Q.D.; Jan, N.D.; Mahar, A.N.; Khuhro, R.D.; Nizamani, S.M.; Panhwar, A., 2008: Monitoring of ambrosia bark beetle through installation of sticky color traps at different heights in mango trees. International Journal of Fruit Science 7(3): 65-79

Goodwin, R.H., 1991: Replacement of vertebrate serum with lipids and other factors in the culture of invertebrate cells, tissues, parasites, and pathogens. Culture medium supplementation with vertebrate serum results in the selection of fibroblastoid insect cell lines and a general decline during continuous subculturing of both morphologic and functional differentiation of the surviving cells. Essent...

Kon, S.; Pustiglioni, F.E.; Cruz,; Novaes, A.B.; Dotto, C.A., 1972: Oral hygiene. Toothbrushing: various technics. Revista Da Associacao Paulista de Cirurgioes Dentistas 26(6): 317-324