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The pineal and regulation of fibrosis pinealectomy as a model of primary biliary cirrhosis roles of melatonin and prostaglandins in fibrosis and regulation of thymus derived lymphocytes


, : The pineal and regulation of fibrosis pinealectomy as a model of primary biliary cirrhosis roles of melatonin and prostaglandins in fibrosis and regulation of thymus derived lymphocytes. Medical Hypotheses 5(4): 403-414

Pinealectomy [in rats] led to increased formation of fibrous tissue in the abdominal cavity, increased skin pigmentation and elevated cholesterol and alkaline phosphatase levels. It also led to reduced formation and/or action of prostaglandin(PG)E1 and thromboxane(TX)A2. PGE1 plays an important role in enhancing function of T [thymus-derived] suppressor lymphocytes, which control overactive antibody-producing B [bone marrow-derived] lymphocytes. In primary biliary cirrhosis there were increased skin pigmentation, hepatic fibrosis, elevated cholesterol and alkaline phosphatase levels, defective T lymphocytes and hyperactive B lymphocytes. Primary biliary cirrhosis may be a pineal deficiency disease. Serotonin is important in the pineal; the serotonin antagonist methysergide may cause retroperitoneal fibrosis by interfering with pineal function. Melatonin, PGE1 and TXA2 may be important in the regulation of fibrosis in other situations such as collagen diseases, Li-induced fibrosis and cardiomyopathies. Enhancement of formation of PGE1 and TXA1 may be of value in diseases associated with excess fibrosis and defective T suppressor cell function. PGE1 levels may be raised by Zn, penicillin, penicillamine and essential fatty acids. TXA2 levels may be raised by low-dose colchicine. These new approaches to treatment may be safer and more effective than existing ones. They may be valuable in [human] disorders such as cardiomyopathy, Hodgkin's disease and other lymphomas, multiple sclerosis, Crohn's disease, atopy and other diseases in which defective T cell function is suspected.

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