geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The presence of the Ii blood group system on human platelets


, : The presence of the Ii blood group system on human platelets. American Journal of Clinical Pathology 82(1): 74-77

To examine platelets for the Ii antigens, high-titer human IgM anti-I and anti-i antibodies were affinity purified, radiolabeled with 125I and incubated with adult and cord platelets. Saturation binding curves were performed by incubating adult platelets with serial dilutions of concentrated 125I-anti-I. Inhibition binding curves were performed by incubating adult platelets with doubling dilutions of concentrated unlabeled anti-I mixed with 125I-labeled anti-I. Adult platelets bound significantly more anti-I than anti-i, while cord platelets bound more anti-i and anti-i (P < 0.025). Both anti-I and anti-i show a temperature-dependent dose-response curve of maximum binding at 4.degree. C. Binding of 125I-labeled anti-I was inhibited by preincubation with 100-fold concentration of unlabeled anti-I. Platelets evidently express I/i antigens in parallel with that of red blood cells. [Implications with respect to the involvement of the Ii system in immune hemolytic anemia and thrombocytopenia caused by auto-anti-i antibodies produced in patients with infectious mononucleosis are presented.].

US$29.90

PMID: 6741875


Other references

Nefedov P.P.; Lazareva M.A.; Belenkii B.G.; Frenkel S.Ya; Koton M.N., 1979: Gel permeation chromatography of soluble poly electrolytes part 1 peculiarities of the elution behavior of synthetic poly electrolytes in amide solvents. The elution behavior of some aliphatic and aromatic polyacids and their derivatives in N,N'-dimethylformamide and N,N'-dimethylacetamide was investigated by gel permeation chromatography on Styragels and macroporous glasses. An abnormall...

Fulhage, C.D., 1998: Gaseous emissions from manure management systems: an overview. Preliminary data in Missouri suggests that lagoon surface:volume ratio has a significant effect on the fraction of excreted nitrogen volatilized in the lagoon. Mature lagoons with a specific surface area of 0.0221 msuperscript 2/kg pig (0.106 ftsu...

Las-Casas, F.M.G.; Azevedo Júnior, S.M.; Dias Filho, M.M., 2012: The community of hummingbirds (Aves: Trochilidae) and the assemblage of flowers in a Caatinga vegetation. We studied hummingbirds and their food plants in an area of caatinga vegetation. We specifically examined their seasonal use of this habitat, migratory and non-migratory status, their foraging strategies and community roles The study was conducted...

Krause, E.G.; Will, H.; Böhm, M.; Wollenberger, A., 1975: The assay of glycogen phosphorylase in human blood serum and its application to the diagnosis of myocardial infarction. Methods are described (a) for the estimation of glycogen phosphorylase activity (EC 2.4.1.1) in human blood serum based on the chemical determination of liberated orthophosphate or on the enzymic determination of glucose 1-phosphate in a coupled a...

Rabl, H., 1923: Die Entwicklung des Glandula hyoidea des Meerschwein chens. Anatomischer Anzeiger Jena (Verh Anat Gesell): 57 pp 157-160

Humphreys, D.G.; Mather, D.E., 1996: Heritability of beta-glucan, groat percentage, and crown rust resistance in two oat crosses. Parent-offspring regression was used to estimate heritability for three traits (beta-glucan content, groat percentage, and resistance to crown rust) (Puccinia coronata Cda. f. sp. avenae Eriks.) in oat (Avena sativa L.). The populations used were...

Schiff, L.; O'donnell, J.F., 1962: The isolated perfused rat liver. Acta Hepato-Splenologica 9: 223-226

Mesas, Cézar.E.; Pappone, C.; Lang, C.C.E.; Gugliotta, F.; Tomita, T.; Vicedomini, G.; Sala, S.; Paglino, G.; Gulletta, S.; Ferro, A.; Santinelli, V., 2004: Left atrial tachycardia after circumferential pulmonary vein ablation for atrial fibrillation: electroanatomic characterization and treatment. OBJECTIVES The purpose of this study was to evaluate the electroanatomic characteristics of left atrial tachycardia (AT) in a series of patients who underwent circumferential pulmonary vein ablation (CPVA) and to describe the ablation strategy and...

White, S.S.; Fenton, S.E.; Hines, E.P., 2011: Endocrine disrupting properties of perfluorooctanoic acid. Perfluoroalkyl acids (PFAAs) have attracted attention in recent years for their environmental ubiquity, as well as their toxicity. Several PFAAs are found in human tissues globally, as humans are exposed on a daily basis through intake of contamin...

Fischer R.P.; Griffen W.O.Jr; Clark D.S., 1968: Post operative renal failure human low cardiac output. Journal-Lancet 88(2): 42-46