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The treatment of gram negative bacillary septicemia with cefoperazone

, : The treatment of gram negative bacillary septicemia with cefoperazone. Infection 9(SUPPL 1): S58-S60

Therapy with cefoperazone (4 g/day i.v.) was successful in 11 of 14 cases of gram-negative bacillary septicemia (78%). The 3 failures were related to Bacteroides fragilis and Acinetobacter sp. infections and to 1 episode of endocarditis caused by Escherichia coli. Minimal bactericidal concentrations of cefoperazone for the causative pathogens were similar to those of gentamicin. A serum bactericidal activity of > 1:8 was achieved in 11 of 12 patients 1 h after the administration of cefoperazone. Continuous infusion of cefoperazone maintained the serum bactericidal activity at a constant value of > 1:8. The clinical results were equally good with intermittent and continuous therapy. Side-effects were minor, rare and most likely not related to cefoperazone.


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