geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate


, : The value of comparative bioavailability studies of marketed drugs in drug control. An example with erythromycin stearate. Methods and Findings in Experimental and Clinical Pharmacology 9(7): 445-447

As a part of the quality control of drugs The National Medicine Control Laboratory in Finland has started comparative bioavailability studies of synonym preparations in human volunteers by taking all the products containing the same active ingredients for absorption studies at the same time. The first study, which is presented as an example of the importance of these studies, covered three erythromycin stearate preparations containing 250 mg of erythromycin. 12 volunteers took 2 tablets of every product at one week intervals in a cross-over fashion, and the serum erythromycin levels were measured microbiologically for 12 hr. Disintegration and dissolution tests were also performed. One of the products was coated with an acid-resistant film and was not dissolved in pH 1.2, whereas the conventional tablets lost all antimicrobial activity after 15 min in pH 1.2. In phosphate buffer, pH 6.6, all the tablets dissolved rapidly and retained antimicrobial activity. One of the conventional tablets showed only a 50% bioavailability as compared to the two others and was subsequently withdrawn from the market. Thus, it is important to conduct comparative post-marketing bioavailability studies with drugs which earlier have shown good bioavailability.

US$29.90

PMID: 3683018


Other references

E.K.idir, O.A.; Nadya ; Badr, A.M.; Murgos, F.I., 1989: Molasses blocks containing oil seed cake and or urea versus a concentrate supplement in a basal hay diet for feeding Sudan Desert lambs. In a 12-week feeding trial, 3 groups of Sudan Desert lambs, about 20.2 kg, were given Sudan grass hay ad libitum and molasses urea block, molasses urea block plus 11% oilseed cake or concentrate. Average daily gain was 61, 121 and 117 g for the 3...

Vigna S.R., 1979: Distinction between cholecystokinin like and gastrin like biological activities extracted from gastro intestinal tissues of some lower vertebrates. A technique which allows differentiation between cholecystokinin-like (CCK-like) and gastrin-like biological activity is described. Contractions of 2 strips of digestive smooth muscle with differing CCK/gastrin specificities, mounted in parallel a...

Kaplan, Moises, 2001: On the relevance of the character absence of epicoracoid horns in the systematics of anurans. Several authors consider the character "absence of epicoracoid horns" a synapomorphy of the group that includes the anuran families Dendrobatidae, Hyperoliidae, Microhylidae, Ranidae and Rhacophoridae (i.e., Ranoidea). However, others ha...

Moguedec, G. le, 1995: Modelling of agricultural supply and EU agricultural policy: a study of a reformed 1995 CAP incorporating limitations on direct subsidies. Much research has gone into how the CAP reform can best be implemented. This study uses the AROPAJ model to examine different CAP scenarios and compare their impact. Two scenarios in particular were compared: 1995 CAP and a reformed 1995 CAP, char...

Slots, J.; MacDonald, E.S.; Nowzari, H., 1999: Infectious aspects of periodontal regeneration. Periodontology 2000 19: 164-172

Mishell, R.I.; Fahey, J.L., 1963: Molecular localization of genetically determined antigens in the immunoglobulins of mice. Abstract only.

Connell, J.G., 1992: A 'minimalist' approach to participatory extension. In diverse production environments, farming systems research faces a fundamental limitation: any technology generated from research for extension to farmers will tend to be site-specific. The solution to this lies, not in refining the research pro...

Wilkins, V.L., 1989: Siblings' joint leisure activities and their correlates in children with and without mental retardation. The study examined children's joint leisure activities with their younger siblings with and without mental retardation. Data were collected from mothers and older siblings in 29 families with a child with mental retardation (mental retardatio...

Ficek, W., 1958: Some unusual appendicitis-like conditions in childhood. Munchener Medizinische Wochenschrift 100(31): 1135-1136

Boman,C.; Israelsson,S.; Ohman,M.; Lundmark,B., 2008: Combustion properties and environmental performance during small scale combustion of pelletized white hardwood raw material. The availability of traditional softwood raw material for fuel pellets production is presently very limited in Scandinavia and white hardwoods (e g birch and aspen) might be a potential feedstock. The over all aim of this work was to evaluate the...