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Tritiated peptides 12. synthesis and biological activity of tritium labeled 8 phenylalanine substance p


, : Tritiated peptides 12. synthesis and biological activity of tritium labeled 8 phenylalanine substance p. Journal of Medicinal Chemistry 25(10): 1209-1213

Substance P was prepared 3H labeled at Phe8 by catalytic deiodination of a protected precursor. Synthesis of the precursor was by solid-phase methodology on polydimethylacrylamide resin and by condensation in solution of fragments covering sequences 1-4, 5-7 and 8-11. Free peptide made by each route analyzed satisfactorily and had the same chromatographic characteristics as unlabeled substance P. It was indistinguishable from the latter by radioimmunoassay when N and C terminally directed antisera were used and in the ability to cause contractions of isolated guinea pig ileum. Specific radioactivity was 23 Ci/mmol.

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